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It’s normal to feel discomfort after a coronavirus shot.

Once a vaccine goes into your arm, blood flow increases and immune cells rush to the scene. This can result in pain at the injection site — the most common side effect of all three US-authorized coronavirus vaccines.

The reaction is more common after Pfizer’s and Moderna’s vaccines than Johnson & Johnson’s. Less than 50% of participants in Johnson & Johnson’s clinical trial reported pain at the injection site, compared with 92% of Moderna participants and 84% of Pfizer participants. 

When our immune systems detect the ingredients of a vaccine, they also release inflammatory chemicals to protect us. That’s why people can develop a fever, muscle pain, fatigue, or headaches shortly after their shots.

Fatigue was the second-most common side effect in Moderna’s and Pfizer’s trials. Nearly 69% of Moderna participants and 63% of Pfizer participants reported it.

But headaches were slightly more common than fatigue among Johnson & Johnson participants: 39% reported headaches, compared with 38% who reported fatigue.

Here’s a breakdown of how vaccine side effects differ by age and manufacturer:

Fatigue and headaches are more common after dose two

The Centers for Disease Control and Prevention released a report on Monday that examined side effects among more than 1.9 million Americans who’d received both doses of Pfizer’s or Moderna’s vaccines.

Overall, side effects were slightly more common after both of Moderna’s shots than Pfizer’s. And side effects across the board were more numerous and severe after the second dose of either vaccine.

Reports of injection-site pain rose from 68% after dose one of either vaccine, to 72% after dose two. Fatigue rose from 31% to 54% from the first to second shot, while headaches rode from 26% to 47%.

Nearly 82% of Moderna recipients reported some reaction at the injection site …read more

Source:: Business Insider


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